​Professionals in skin


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September 13th - 17th, 2017

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October 5th - 6th, 2017

Liquid nitrogen cryosurgical equipment

Treatment techniques

Mechanism of cell injury

The mechanism of cell injury from freezing is both chemical and mechanical, and a main effect is directly related to the formation of ice crystals within the cells. Rapid freezing does not allow sufficient time for intracellular water to leave the cell and, consequently, it leads to intracellular ice crystallization and mechanical rupture of the cell membrane. During slow thawing, recrystallization takes place – i.e. small ice crystals aggregate to form larger crystals – leading to further mechanical damage of the cell membranes.


  • Apply a quick freeze/slow thaw technique.
  • Repeated freeze/thaw cycles may improve efficacy.
  • Extend the ice ball beyond the target margins to ensure freezing of the entire target.

​Using open spray tip technique

Select a spray aperture appropriate for the lesion to be treated. To obtain in-depth freezing it is essential to place the spray aperture close to the lesion (5 - 10 mm distance), as the liquid content of the spray is higher close to the aperture.

When possible, raised warts should be approached tangentially from at least two sides. This allows the ice ball to move down through the wart while sparing the surrounding tissue. Spraying directly at the lesion (perpendicular to the surface) will cause more lateral spread with less penetration. To avoid this, apply the spray intermittently or use a smaller spray aperture.

Superficial desquamation is obtained using the larger apertures (“A” or “B”) at approx. 5 cm distance (higher vapor content) and slowly “painting” the surface with vaporized nitrogen.

Using spray cone technique

Spray cones in combination with an open spray aperture may be used to confine the lateral spread of the freeze. Select a cone size, which will fully cover the target area and spray directly into the cone at close distance. Small diameter hard, clear cones are available for small to medium size lesions. For larger lesions rubber cones are available, which may be shaped to follow the margins of the lesion more accurately.

​To watch the spray application technique click below:

​For more videos of our products visit CORTEX TECHNOLOGY's youtube channel here

Using closed contact probe technique

Closed contact probes provide in-depth freezing with minimal lateral spread. Select a probe size fitting the size of the lesion. Make the lesion wet with a drop of water or contact gel prior to freezing to facilitate the thermal transfer between skin and probe tip. Apply the contact probe when still warm applying light pressure and pull the trigger handle. Allow approx. 5 sec. extra freezing time to cool down the contact probe and keep freezing until a 1 mm halo is seen around the probe tip. Then stop the freezing and allow a few seconds for the probe tip to come loose. This “quick freeze slow thaw” procedure using the contact probe technique ensures a very effective treatment with high penetration and accuracy.

To watch the closed probe technique click below:

For more videos of our products visit CORTEX TECHNOLOGY's youtube channel here

CORTEX TECHNOLOGY ApS · Plastvaenget 9, 9560 Hadsund · Denmark · +45 98574100 · Fax: +45 98572223 · cortex@cortex.dk · CVR: 78880813 ·VAT: DK46062752